HMB - muscle catabolism
HMB (β-hydroxy β-methylbutyrate) is the most-studied muscle-preservation ingredient in the world, with over 50 published clinical trials. Key research:
- Wilson et al. (2013) - HMB reduces muscle protein breakdown during caloric deficit.
- Stout et al. (2013) - HMB-Ca preserves lean mass in older adults during bed rest.
- Phillips (2015) - HMB attenuates muscle damage during prolonged caloric restriction.
MYOTIDE dose: 1,000 mg/day - matches the dose used in the cited muscle-preservation studies.
Creatine - ATP support
Creatine monohydrate has 30+ years of safety and efficacy research, the most of any sports nutrition compound. Relevant to GLP-1 users:
- Kreider et al. (2017) - International Society of Sports Nutrition position stand confirms creatine safety and efficacy.
- Candow et al. (2019) - low-dose creatine (3-5 g/day) supports strength in older adults, even with reduced training.
MYOTIDE dose: 500 mg/day - a low-dose maintenance level appropriate for daily gummy delivery and combined-ingredient stacks.
L-Leucine - mTOR activation
Leucine is the primary amino acid that activates the mTOR pathway, the body's central muscle-building switch.
- Norton & Layman (2006) - Leucine threshold for maximum mTOR activation.
- Devries et al. (2018) - Leucine supplementation improves anabolic response in older adults.
MYOTIDE dose: 250 mg/day - synergistic with food-derived leucine, not a meal-replacement dose.
Hydrolyzed Collagen I+III - skin elasticity
Type I and III collagen peptides have established efficacy for skin elasticity and dermal density.
- Proksch et al. (2014) - Oral collagen peptides improve skin elasticity in women.
- Bolke et al. (2019) - 12-week collagen supplementation increases skin hydration and density.
MYOTIDE dose: 200 mg/day - supports skin matrix maintenance during periods of rapid weight loss.
Vitamin D3 - energy & recovery
Vitamin D3 supports musculoskeletal function, mood, and immune resilience.
- Holick (2007, NEJM) - Vitamin D deficiency is widespread and impacts muscle function.
- Beaudart et al. (2014) - D3 supplementation improves muscle strength in adults.
MYOTIDE dose: 2,000 IU/day - a safe maintenance dose appropriate for daily use.
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