The Science

The research behind every gram.

Every ingredient in The Preserve Stack was chosen — and dosed — from published, peer-reviewed research, then printed in full on the label. No proprietary blend. No marketing math. Here's the research that shaped the formula.

~40%can be muscle

Why the stack exists

GLP-1 medications work — but the weight you lose isn't only fat. Published research shows a large share of medically-induced weight loss can come from lean muscle. That's the exact loss The Preserve Stack is built to help you hold onto.

Prado et al., Lancet Diabetes & Endocrinology (2024) →
Ingredient by ingredient

The research behind each active.

Each ingredient earns its place with published science. The studies below support the ingredients we chose — read them yourself.

★ Hero Ingredient

HMB-Calcium

1,000 mg

Helps preserve lean muscle during a calorie deficit — the most-studied muscle-preservation ingredient in the stack.

ISSN Position Stand · J. Int. Soc. Sports Nutrition

The International Society of Sports Nutrition's official position: HMB supports recovery and can help preserve lean mass, especially during periods of calorie restriction.

View study →

Holeček · J. Cachexia, Sarcopenia & Muscle (2017)

Reviews how HMB acts on the pathways that break muscle down — the same catabolic signalling a deficit ramps up.

View study →
Muscle signal

L-Leucine

250 mg

The amino acid that signals your body to build and maintain muscle (the mTOR pathway).

Casperson et al. · Clinical Nutrition (2012)

Daily leucine chronically improved muscle protein synthesis in older adults — the body's "build and maintain" signal.

View study →
Strength & lean mass

Creatine Monohydrate

500 mg

Supports strength and lean mass — and works independent of insulin, even when you're eating less.

ISSN Position Stand · J. Int. Soc. Sports Nutrition (2017)

One of the most-researched and well-tolerated supplements in sports nutrition for supporting lean mass and strength.

View study →
Emerging research

BHB Ketone Salts

100 mg

An early, fast-moving area of GLP-1 muscle research — one of the ingredients biohackers watch most closely.

University of Alberta · Dyck Lab (Oct 2025)

Early research found ketone supplementation alongside semaglutide helped protect muscle in a preclinical model. Promising, but still emerging — not proof of a result in people.

Read the research →
Foundation

Vitamin D3

2,000 IU

Supports normal muscle function — and it's one of the most common nutrient shortfalls when you're eating less.

Holick · New England Journal of Medicine (2007)

The landmark NEJM review on vitamin D — a nutrient central to normal muscle function and widely under-supplied.

View study →
Skin cofactor

Vitamin C

50 mg

The cofactor your body uses to make collagen — paired with the collagen peptides below.

Authorized structure/function claim · EU (EFSA) & US FDA

An officially authorized claim: "Vitamin C contributes to normal collagen formation."

Skin matrix

Hydrolyzed Collagen I+III

200 mg

Provides the Type I & III collagen peptide types your skin's structural matrix is built from.

Proksch et al. · Skin Pharmacology & Physiology (2014)

Studied the specific collagen peptide types researched for skin elasticity and hydration.

View study →

How to read this page

The studies above are the research behind each ingredient — they're why we chose it and how we set the dose. They are not a claim that MYOTIDE itself has been clinically tested, and every dose is a daily companion amount, printed transparently on the label rather than hidden in a blend.

MYOTIDE is built to run alongside your GLP-1 — not instead of it. New medication or questions? Always loop in your doctor.

See every ingredient & dose For healthcare pros: Clinical Dossier

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

MYOTIDE is a dietary supplement and a companion to GLP-1 care — not a substitute for medication or medical advice.